Control and germ-free mice at three different ages (4, 8, and 12 weeks) were trained in contextual fear-conditioning, then subsequently tested the following day. Additionally, we examined memory induced functional connectivity of hippocampal networks. Here, we examined whether the effects of gut microbiome disruption on neurogenesis are age-dependent, given that both neurogenesis and the microbiome show age-related changes. Recent evidence indicates that disruption of the gut microbiome leads to altered hippocampal neurogenesis. The gut microbiome has profound effects on development and function of the nervous system. Cumming School of Medicine, Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada.Vu †, Sampson Law, Alexandria Evans and Jonathan R.
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